Ethylbisiminomethyguaiacol Manganese Chloride

EthylbisiminomethyguaiacolEthylbisiminomethyguaiacol Manganese Chloride is an ingredient compound that is often found in sunscreen products. The ingredient has been found to prevent damage caused by UVB light while increasing the vitality of cells post-exposure. Ethylbisiminomethyguaiacol Manganese Chloride is known for delivering antioxidant activity.

Antioxidant activity limits the impact of free radicals, uncharged molecules with an unpaired valence electron. Free radicals cause damage to the skin cells by introducing them oxidative stress. As a result, healthy cells are contaminated. The damaged caused by free radicals leads to a decrease in collagen. Collagen is a protein that functions as the building block of the body.

Guaiacol is an organic compound that occurs naturally and is derived from the guaicum and wood creosote. The compound is considered a “precursor” to flavoring agents such as eugenol and vanillin. Guaiacol derivatives have been used for medicinal purposes as an antiseptic, in anesthetics, and as an expectorant.

Ethylbisminomethyguaiacol Manganese Chloride has been described as a synthetic superoxide dismutase/catalase mimetic, identified as EUK-134 in the Journal of investigative Dermatology (2004). According to the investigation, the compound has been shown to alleviate UVB damage while stabilizing the p53 protein, a protein responsible for censoring and mediating UVB damage (Decaraene, Smaers, et.al, 2004).

Decraene, D, Smaers, K, et.al (2004). A synthetic Superoxide Dismutase/Catalase mimetic (EUK-134) Inhibits Membrane-Damaged-Induced Activation of Mitogen-Activated Protein Kinase Patheways and Reduces p53 Accumulation in Ultraviolet-B Exposed Primary Human Keratinocytes. Journal of Investigative Dermatology. 122, 489-491; doi: 10.1046/j.0022.202X.2004.2214.x